A colloidal drug delivery system (CDDS) based on a novel surface modification process help to reserve the constraining activity of surfaces. Aquasome is a nanoparticle submicronic structure (diameter below 1um) made up with carbohydrates. They received much attention to develop a drug delivery system as an alternative to liposome technology in order to overcome the problems related to the stability of these vesicles in biological fluids. Aquasome a molecular carrier, consist of ceramic core to which glassy carbohydrates are then allowed to adsorb, which is then absorbed with pharmaceuticals. The carbohydrate coating functions as a dehydroprotectant and stabilizes subsequently non-covalently bound drug molecule. In the present study aquasomes charged with diclofenac sodium a low solubility drug were obtained through the formation of an inorganic core of calcium phosphate covered with cellobiose film and further adsorption of the Diclofenac sodium. The prepared aquasomes were evaluated for the different parameters. The electron microscopy, partical size analysis and measurement of zeta potential reveals that prepared core were smaller and spherical nanometric in size (60-120nm). Coating of cellobiose on the surface of core was further confirmed by zeta potential measurement. It was noted that, the zeta potential of coated particle decrease from + 2.73 to -20.8 mv. The release of drug from aquasome is about 70% within 30 min and the remaining being gradually release over a period of 6 hours. The aquasome shows a loading efficacy up to 92% and the loading capacity up to 50% w/w. Thus, aquasomes of diclofenac sodium were successfully developed.
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